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Amiodarone

Enzyme Inhibitors
CATEGORIES

Enzyme Inhibitors, Anti-Arrhythmia Agents, Vasodilator Agents


ALIASES

Amiodaron Hameln, Amiodaron Stragen, Cordarone, Cordarone®, Nexterone, Atlansil, Cordarone, Nexterone, Pacerone, Tachyra


SUBSTANCES

amiodarone, amiodarone hydrochloride


ENVIRONMENTAL CONCERN: MODERATE
An antianginal and antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting Na,K-activated myocardial adenosine triphosphatase. There is a resulting decrease in heart rate and in vascular resistance. [PubChem]

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MODERATE
The T-value in the score for hazard refers to chronic toxicity. Underlying data for P, B, T and risk are from Fass.

Below is Hazard and Risk from Fass environmental information for Cordarone (amiodarone) (downloaded 2018-08-20)


Hazard
Persistence: "Test showed 0% degradation in 28 days (OECD 301B). Amiodarone fails to pass the criteria for ready biodegradability which justifies the phrase “Amiodarone is potentially persistent”."

Bioaccumulation: Log Pow = 7.57 "(experimental data, method unknown)."

Toxicity: There are data for 3 trophic levels, most sensitive algae (Pseudokirchneriella subcapitata) NOEC 72 hours = 12 microg/L.

Risk
PEC/PNEC is based on sales data in Sweden in year 2015. PEC / PNEC = 0.18034 which gives the risk low.

Pharmaceutical analyses of water in Stockholm County
Amiodarone has been analysed but not detected in treated wastewater, surface water and drinking water in Stockholm County in the last five years (2012–2016).

REFERENCES

  1. Fass.se för vårdpersonal
  2. SLL. Sammanställning av läkemedelsprovtagningar - Bearbetning av regional försäljningsstatistik av läkemedel samt datamaterial från Stockholms läns landstings mätprogram för läkemedelssubstanser i vattenmiljö, 2012–2016.