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Atovaquone

CATEGORIES


ALIASES

Atovakvon/Proguanil Glenmark, Horisto, Malarone, Malarone®, Malarone® Junior, Malastad, Wellvone, Wellvone®


SUBSTANCES

atovaquone


ENVIRONMENTAL CONCERN: MODERATE
A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols. [PubChem]

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MODERATE
The T-value in the score for hazard refers to chronic toxicity. Underlying data for P, B and T comes from Fass.se, see below.

Fass environmental information for atovaquone, Malarone (atovaquone, proguanil) (downloaded 2018-06-26)


Hazard
Persistence: It can not be ruled out that atovaquone is persistence because data is missing.

Bioaccumulation: Log Kow = 5.31 at pH 7

Chronic toxicity: There is NOEC for 8 days for 1 trophic level: crustacean 0.083 microg/L.

PBT/vPvB assessment
"The appropriate degradation data are not available to assign PBT/vPvB criteria."

Risk
"Risk of environmental impact of atovaquone cannot be excluded, since there is not sufficient ecotoxicity data available."

REFERENCES

  1. Fass.se för vårdpersonal