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Bromocriptine

Hormone Antagonists
CATEGORIES

Hormone Antagonists, Antiparkinson Agents, Dopamine Agonists, Antidyskinetics


ALIASES

Parlodel, Pravidel, Pravidel®, Cycloset, Ergoset, Parlodel, Parlodel Snaptabs, Pravidel


SUBSTANCES

bromocriptine, bromocriptine mesylate


ENVIRONMENTAL CONCERN: MODERATE
Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It is indicated for the management of signs and symptoms of Parkinsonian Syndrome. Bromocriptine also inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. It also causes sustained suppression of somatotropin (growth hormone) secretion in some patients with acromegaly. Bromocriptine has been associated with pulmonary fibrosis.

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MODERATE
Underlying data for P, B, T and risk are from Fass.

Below is Hazard and Risk from Fass environmental information for Pravidel (bromocriptine) (downloaded 2018-10-31)


Hazard
Persistence: No data.

Bioaccumulation: "A computed Log P of 3,8 (XLogP3) indicates that bromocriptine has low potential for bioaccumulation. Log P < 4 which justifies the phrase “Bromocriptine has low potential for bioaccumulation”."

Toxicity: No data.

Risk
"According to the European Medicines Agency guideline on environmental risk assessment of medicinal products (EMA/CHMP/SWP/4447/00), use of bromocriptine is unlikely to represent a risk for the environment, because the predicted environmental concentration (PEC) is below the action limit 0,01 μg/L. Risk för miljöpåverkan av bromokriptin kan inte uteslutas då ekotoxikologiska data saknas."

Pharmaceutical analyses of water
Bromocriptine has been found in sludge (6.3 microg/kg) and treated wastewater (5.6 ng/L) at Swedish national measurements in 2010 but not 2014. The reduction rate has been set between 55 and 75 percent. Bromocriptine has been below the LOQ (limit of quantification) in measurements of treated wastewater within the Stockholm region 2012-2016, as well as in measurements 2017 of treated wastewater, surface water and drinking water. In the report on drug residues in the Stockholm aquatic environment, bromocriptine has been found in treated wastewater from Henriksdal wastewater treatment plant and in sludge from the same wastewater treatment plant.

Artikeln Predicted critical environmental concentrations for 500 pharmaceuticals
Critical effect concentration (CEC) för bromocriptine is 9.0 ng/L. Log P is set to 4.0.

REFERENCES

  1. Fass.se för vårdpersonal
  2. IVL Swedish Environmental Research Institute Ltd. Fick J, Lindberg RH, Kaj L, Brorström-Lundén E. Results from the Swedish National Screening Programme 2010. Subreport 3, B 2014 Pharmaceuticals.
  3. IVL Swedish Environmental Research Institute Ltd Fick J, Lindberg RH, Fång J, Magnér J, Kaj L, Brorström-Lundén E. Screening 2014. Analysis of pharmaceuticals and hormones in samples from WWTPs and receiving waters. Rapport C 135.
  4. SLL. Sammanställning av läkemedelsprovtagningar - Bearbetning av regional försäljningsstatistik av läkemedel samt datamaterial från Stockholms läns landstings mätprogram för läkemedelssubstanser i vattenmiljö, 2012–2016.
  5. Stockholm Vatten. Läkemedelsrester i Stockholms vattenmiljö. 2010. ISBN 978-91-633-6642-0.
  6. Fick J, Lindberg RH, Tysklind M, Larsson DG. Predicted critical environmental concentrations for 500 pharmaceuticals. Regul Toxicol Pharmacol. 2010;58:516-23.