pCure Labs
LABS

Search substance info

Cefotaxime

Anti-Bacterial Agents
CATEGORIES

Anti-Bacterial Agents, Cephalosporins


ALIASES

Cefotaxim AB Unimedic Vial Mate, Cefotaxim Copyfarm, Cefotaxim MIP, Cefotaxim Sandoz, Cefotaxim Stragen, Cefotaxim Teva, Cefotaxim Villerton, Claforan, Claforan®


SUBSTANCES

cefotaxime, cefotaxime sodium


ENVIRONMENTAL CONCERN: HIGH
Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis).

Read More

HIGH

This substance is an antibiotic (also called, anti-bacterial agent). All antibiotics are suspected to cause antibiotic resistance and we should therefore try to limit releasing it to Nature via our wastewater streams.

Some key facts from WHO

  • Antibiotic resistance is one of the biggest threats to global health. food security, and development today
  • Antibiotic resistance can affect anyone, of any age, in any country.
  • Antibiotic resistance occurs naturally, but misuse of antibiotics in humans and animals is accelerating the process.
  • A growing number of infections – such as pneumonia, tuberculosis, gonorrhoea, and salmonellosis – are becoming harder to treat as the antibiotics used to treat them become less effective.
  • Antibiotic resistance leads to longer hospital stays, higher medical costs and increased mortality.
Underlying information for P, B, T and risk are from Fass.

Below is Hazard and Risk from Fass environmental information for Cefotaxim Villerton (downloaded 2018-10-31)


Hazard
Persistence: No data.

Bioaccumulation: "Log P= -1.4 at neutral pH (predicted by ChemAxon)."

Toxicity: No data.

Risk
Risk of environmental impact of cefotaxime cannot be excluded, since no ecotoxicity data is available.

Article Predicted critical environmental concentrations for 500 pharmaceuticals
Critical effect concentration (CEC) for cefotaxime is 1 300 000 ng/L. Log P is set to 0.6.

Antibiotic resistance
Studies have shown that even low concentrations of antibiotics in the environment can contribute to antibiotic resistance and therefore as little as possible should end up in our environment.

For antibiotics in general, it is recommended that these drugs are used as restrictively as possible without risking the patient's health.

REFERENCES

  1. Fass.se för vårdpersonal
  2. Fick J, Lindberg RH, Tysklind M, Larsson DG. Predicted critical environmental concentrations for 500 pharmaceuticals. Regul Toxicol Pharmacol. 2010;58:516-23.
  3. Bengtsson-Palme J, Larsson DG. Concentrations of antibiotics predicted to select for resistant bacteria: Proposed limits for environmental regulation. Environ Int. 2016;86:140-9.