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Clemastine

Anti-Allergic Agents
CATEGORIES

Anti-Allergic Agents, Antipruritics, Histamine H1 Antagonists


ALIASES

Tavegil, Tavegyl, Tavegyl®, Clemastine Fumarate, Tavegil, Tavegyl, Tavist, Tavist-1


SUBSTANCES

clemastine, clemastine fumurate


ENVIRONMENTAL CONCERN: MODERATE
An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. [PubChem]

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MODERATE
Underlying information för P, B, T and risk are from Fass.

Below is Hazard and Risk from Fass environmental information for Tavegyl (clemastine) (downloaded 2018-10-31)


Hazard
Persistence: No data.

Bioaccumulation: "Log Pow is 6.4 calculated using a Novartis in-house program."

Toxicity: No data.

Risk
Risk of environmental impact of clemastine cannot be excluded, since no ecotoxicity data are available.

Pharmaceutical analyses of water in Stockholm County
Clemastine has been found in purified wastewater within Stockholm County during the last five-year period (2012-2016) but was not detected in measurements 2017.

The article Predicted critical environmental concentrations for 500 pharmaceuticals
Critical effect concentration (CEC) for clemastine is 0.74 ng/L. Log P is set to 5.5.

REFERENCES

  1. Fass.se för vårdpersonal
  2. SLL. Sammanställning av läkemedelsprovtagningar - Bearbetning av regional försäljningsstatistik av läkemedel samt datamaterial från Stockholms läns landstings mätprogram för läkemedelssubstanser i vattenmiljö, 2012–2016.
  3. Fick J, Lindberg RH, Tysklind M, Larsson DG. Predicted critical environmental concentrations for 500 pharmaceuticals. Regul Toxicol Pharmacol. 2010;58:516-23.