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Clonidine

Antihypertensive Agents
CATEGORIES

Antihypertensive Agents, Sympatholytics, Analgesics, Adrenergic alpha-2 Receptor Agonists


ALIASES

Catapres, Catapres-TTS, Catapres-TTS-3, Catapresan, Catapresan 25, Catapresan TTS-1, Catapresan TTS-2, Catapresan TTS-3, Catapresan®, Dixarit, Kapvay, Nexiclon, Nexiclon Xr, Run Rui, Velaril, Winpress


SUBSTANCES

clonidine, clonidine hydrochloride


ENVIRONMENTAL CONCERN: MODERATE
Clonidine, an imidazoline-derivative hypotensive agent is a centrally-acting α2-adrenergic agonist. It crosses the blood-brain barrier and acts in the hypothalamus to induce a decrease in blood pressure. It may also be administered as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone. Clonidine may be used for differential diagnosis of pheochromocytoma in hypertensive patients. Other uses for clonidine include prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD). Clonidine also exhibits some peripheral activity.

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MODERATE
Detailed information about this substance is missing and will added when a credible source of information has been identified.