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Antifungal Agents

Antifungal Agents, 14-alpha Demethylase Inhibitors, Anti-Infective Agents, Local


Antifungol, Apocanda-Lösung, Canesten, Canesten®, Klotrimazol Mylan, Aspiera Anti-fungal, Athlete S Foot Afac, Athletes Foot Antifungal Antifungal, Atopalm Clotrimazole Antifungal, Best Choice Clotrimazole, Budpak Antifungal Clotrimazole, Canesten, Canifug, Careone Clotrimazole, Clotrimaderm, Clotrimazoil Antifungal, Clotrimazole, Clotrimazole 1% Athletes Foot, Clotrimazole 7, Clotrimazole Antifungal, Clotrimazole Athletes Foot, Clotrimazole Jock Itch, Cvs Antifungal Ringworm, Cvs Pharmacy Clotrimazole 3, Cvs Pharmacy ITCH RELIEF ANTIFUNGAL, Dermatin Antifungal, Dr Sheffield Athletes Foot, Empecid, Equaline Clotrimazole Antifungal, Family Care Clotrimazole Antifungal, Family Wellness Antifungal, FemCare, Femmesil, First Aid Research Antifungal .5oz, First Aid Research Antifungal Cream 1oz, Foot Care Clotrimazole, Footlogix, Footlogix Intensive Care diabetic formula, Fungicip, Fungicure Intensive, Fungicure Manicure Pedicure, Fungicure Pumpspray, Gehwol Med Foot, Gehwol Nail Protection Pen, Gerlasan Hand, Good Neighbor Pharmacy Clotrimazole, Good Neighbor Pharmacy Clotrimazole 3, Good Sense Athletes Foot antifungal, Gyne-Lotrimin, Gyne-lotrimin 3, Gyne-lotrimin 7, Heb Antifungal, Hua Tuo Xian Gao, Jidesheng, Jock Itch, Jock Itch Antifungal, Kroger ATHLETES FOOT, Kroger Jock Itch, Leader Clotrimazole Anti-fungal, Live Better Antifungal, Lotrimin, Lotrimin Antifungal, Lucky Supersoft Athletes Foot, Major Clotrimazole, Makesense, Meijer Athletes Foot, Meijer Clotrimazole 3, Meijer Clotrimazole Antifungal, Mycelex, Myclo-Derm, Myclo-Gyne, Our Family Athletes Foot, Pedesil, Pedesil Maximum Strength, Pro-ex Anti Fungal, Publix athletic foot, Quality Choice Clotrimazole, Rite Aid antifungal ringworm, Shopko Athletes Foot, Smart Sense Athletes Foot antifungal, Soundbody Clotrimazole Antifungal, Sunmark Antifungal, Sunmark Clotrimazole 3, Terrasil Anti-fungal Treatment MAX, Terrasil Jock-itch Treatment MAX, Terrasil Rapid-clear Anti-fungal, Terrasil Ringworm Treatment MAX, Terrasil Tinea Treatment MAX, Theraplus Plus, Topcare Antifungal, Topcare Clotrimazole 3, Upandup Clotrimazole, Walgreens Clotrimazole, Walgreens Clotrimazole 3, Walgreens Clotrimazole Antifungal, Walgreens Jock Itch, Western Family Athletes Foot, Winco Antifungal



An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. [PubChem]

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The T-value in the score for hazard refers to chronic toxicity. Underlying data for P, B and T comes from Fass for Canesten (clotrimazole) (downloaded 2013-06-25). No new environmental information for clotrimazole is published on Fass.se (2018-09-05).

Below information from Fass environmental information for Canesten (clotrimazole) (downloaded 2013-06-25)

Persistence: "CO2 evolution test, guideline, C.4 C (6)). Test results 0% degradation in 28 days (guideline 79/831/EEC)."

Bioaccumulation: "Log POW 4.1 (EU guideline 92/69/EC, A.8). Since log POW 4.1, the substance has high potential for bioaccumulation."

Chronic toxicity: There is NOEC for 3 trophic levels, lowest NOEC for crustacean (Dapnia magna) 10 microg/L.

PBT/vPvB assessment
clotrimazole is not PBT/vPvB.

PEC/PNEC is based on sales data in Sweden in year 2011. PEC/PNEC = 0.013 which gives the risk insignificant.

Pharmaceutical analyses of water in Stockholm County
Clotrimazole has been detected in treated wastewater and surface water in Stockholm County in the last five years (2012–2016). The average reduction rate was 96 %.

Report Pharmaceutial residues in the Stockholm aquatic environment
Clotrimazole has been detected in incoming and outgoing water from Swedish wastewater treatment plants.


  1. SLL. Sammanställning av läkemedelsprovtagningar - Bearbetning av regional försäljningsstatistik av läkemedel samt datamaterial från Stockholms läns landstings mätprogram för läkemedelssubstanser i vattenmiljö, 2012–2016.
  2. Stockholm Vatten. Läkemedelsrester i Stockholms vattenmiljö. 2010. ISBN 978-91-633-6642-0.