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Cyproheptadine

Anti-Allergic Agents
CATEGORIES

Anti-Allergic Agents, Gastrointestinal Agents, Serotonin Antagonists, Antipruritics, Histamine H1 Antagonists


ALIASES

PERIACTIN, Periactin, Periactin®, Peritol, Cipractine, Ciproheptadina, Ciprovit, Ciptadine, Cyheptine, Cyllermin, Cyproheptadine, Cyproheptadine Hydrochloride, Periactin, Periactine, Periatin, Reactin


SUBSTANCES

cyproheptadine, cyproheptadine acefyllinate, cyproheptadine acetylasparate, cyproheptadine cyclamate, cyproheptadine hydrochloride, cyproheptadine hydrochloride anhydrous, cyproheptadine pyridoxalphosphate


ENVIRONMENTAL CONCERN: MODERATE
A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. [PubChem]

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MODERATE
The medicine is now withdrawn from use in Sweden 2009-12-31. The data on hazard and risk are based on previous environmental information on Fass.se.

Pharmaceutical analyses of water
Cyproheptadine was included in the Swedish national screening programme 2010 (for example found in treated wastewater) and also 2014 but then below the LOQ (limit of quantification) for the measurements.

Cyproheptadine has been found in influent wasterwater in the Stockholm region 2012-2016.

REFERENCES

  1. Stockholms läns landsting. Miljöklassificerade läkemedel 2014–2015. Stockholm; 2014.
  2. IVL Swedish Environmental Research Institute Ltd. Fick J, Lindberg RH, Kaj L, Brorström-Lundén E. Results from the Swedish National Screening Programme 2010. Subreport 3, B 2014 Pharmaceuticals.
  3. IVL Swedish Environmental Research Institute Ltd Fick J, Lindberg RH, Fång J, Magnér J, Kaj L, Brorström-Lundén E. Screening 2014. Analysis of pharmaceuticals and hormones in samples from WWTPs and receiving waters. Rapport C 135.
  4. SLL. Sammanställning av läkemedelsprovtagningar - Bearbetning av regional försäljningsstatistik av läkemedel samt datamaterial från Stockholms läns landstings mätprogram för läkemedelssubstanser i vattenmiljö, 2012–2016.