An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females. [Pubchem]
The T-value in the score for hazard refers to acute toxicity. Underlying data for P, B, T and risk are from Fass. Below is Hazard and Risk from Fass environmental information for Androcur (cyproterone) (downloaded 2018-11-01) Hazard Persistence: "CO2 evolution test, guideline OECD 301B (80).Test results 0% degradation in 28 days." Bioaccumulation OECD 117: Log Pow = 3.36. Acute toxicity OECD 202: There are data for 1 trophic level for crustaceans (Daphnia magna) 2.4 mg/L. Risk Risk of environmental impact of cyproterone acetate cannot be excluded, since there is not sufficient ecotoxicity data available. Article Predicted critical environmental concentrations for 500 pharmaceuticals Critical effect concentration (CEC) for cyproterone is 1 786 ng/L. Log P is set to 3.6.
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Fick J, Lindberg RH, Tysklind M, Larsson DG. Predicted critical environmental concentrations for 500 pharmaceuticals. Regul Toxicol Pharmacol. 2010;58:516-23.