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Diphenhydramine

Anti-Allergic Agents
CATEGORIES

Anti-Allergic Agents, Hypnotics and Sedatives, Anesthetics, Local, Histamine H1 Antagonists, Antitussive Agents, Antiemetics, Antidyskinetics


ALIASES

Benylan, DIPHENHYDRAMINE HCL, Desentol®, Diphenhydramine Hydrochloride, Lepheton-Desentol AB Unimedic, Allernix, Banophen, Baramine, Beldin, Belix, Benadryl, Benylan, Childrens Allergy Relief, Childrens Wal-dryl Allergy, Dermodrin, Desentol, Dibondrin, Dimedrol, Diphen, Diphenhist, Diphenhydramine, Diphenhydramine Hydrochloride, Dormarex 2, Genahist, Help I Cant Sleep, Histaprin, Histaxin, Hyrexin, Insomnal, Nightime Sleep Aid, North Antihistamine, Nytol QuickCaps, Nytol Quickgels, Restamin, Siladryl, Silphen Cough, Unisom, Zzzquil, Zzzsleep


SUBSTANCES

diphenhydramine, diphenhydramine hydrochloride


ENVIRONMENTAL CONCERN: MODERATE
A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.

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MODERATE
Underlying data for P, B, T and risk are from Fass.se.

Diphenhydramine has been detected in treated wastewater, surface water and fish in Stockholm County in the last five years (2012-2016).

Below is Hazard and Risk from Fass environmental information for Desentol (diphenhydramine) (downloaded 2018-07-06)


Hazard
Persistence: No data.

Bioaccumulation: Log P of 3.27.

Toxicity: No data.

Risk
Sales data for Sweden is available for 2015. PEC = 0.000872 microg/L. "According to the European Medicines Agency guideline on environmental risk assessment of medicinal products (EMA/CHMP/SWP/4447/00), use of diphenhydramine is unlikely to represent a risk for the environment, because the predicted environmental concentration (PEC) is below the action limit 0,01 μg/L."

REFERENCES

  1. SLL. Sammanställning av läkemedelsprovtagningar - Bearbetning av regional försäljningsstatistik av läkemedel samt datamaterial från Stockholms läns landstings mätprogram för läkemedelssubstanser i vattenmiljö, 2012–2016.
  2. Fass.se för vårdpersonal