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Donepezil

CATEGORIES


ALIASES

Aricept, Aricept Evess 5 mg, Aricept®, Azepezil, Donepezil Accord, Donepezil Actavis, Donepezil Aurobindo, Donepezil Jubilant, Donepezil Krka, Donepezil Mylan, Donepezil Navamedic, Donepezil Orifarm, Donepezil Orion, Donepezil Paranova, Donepezil STADA, Donepezil Sandoz, Donepezil Teva, Donepezil bluefish, Zolpezil


SUBSTANCES

donepezil, donepezil hydrochloride, donepezil hydrochloride monohydrate


ENVIRONMENTAL CONCERN: MODERATE
Donepezil (Aricept), is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, donepezil's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. Donepezil has been tested in other cognitive disorders including Lewy body dementia and Vascular dementia, but it is not currently approved for these indications. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, and Down syndrome.

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MODERATE
Detailed information about this substance is missing and will added when a credible source of information has been identified.