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Estriol

Estrogens, combinations with other drugs
CATEGORIES

Estrogens, combinations with other drugs


ALIASES

Aacifemine, Atrocom, Blissel, Colpogym, Donaflor, Estriol BModesto, Estriol Dr. Kade, Estriol Fisher, Estriol Jenapharm, Estriol Lenis, Estriol Wolff, Estrokad, Femmyn, Florgynal, Geliesse, Gelistrol, Gydrelle, Gynest, Gynoflor, Imvaggis, Incurin, Oekolp, Oestriol Aspen, Ortho-Gynest, Ovestin, Ovestinon, Pausanol, Pausigin, Physiogine, Synapause-E3, Trophicreme, Trophigil


SUBSTANCES

estriol


ENVIRONMENTAL CONCERN: HIGH
A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes.

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VERIFIED EFFECT
HIGH

REFERENCES

  1. Tan, B. L. L., D. W. Hawker, J. F. Mueller, F. D. L. Leusch, L. A. Tremblay and H. F. Chapman (2007), "Comprehensive study of endocrine disrupting compounds using grab and passive sampling at selected wastewater treatment plants in South East Queensland, Australia." Environment International 33, 654-669.
  2. Hedgespeth, M. L., Y. Sapozhnikova, P. Pennington, A. Clum, A. Fairey and E. Wirth (2012). "Pharmaceuticals and personal care products (PPCPs) in treated wastewater discharges into Charleston Harbor, South Carolina." Science of The Total Environment 437, 1-9
  3. Vallejo, A., A. Prieto, M. Moeder, A. Usobiaga, O. Zuloaga, N. Etxebarria and A. Paschke (2013). "Calibration and field test of the Polar Organic Chemical Integrative Samplers for the determination of 15 endocrine disrupting compounds in wastewater and river water with special focus on performance reference compounds (PRC)." Water Research 47, 2851- 2862.
  4. Fernandez, M. P., M. G. Ikonomou and I. Buchanan (2007). "An assessment of estrogenic organic contaminants in Canadian wastewaters." Science of The Total Environment 373, 250-269.
  5. Martin, J., D. Camacho-Munoz, J. L. Santos, I. Aparicio and E. Alonso (2011). "Monitoring of pharmaceutically active compounds on the Guadalquivir River basin (Spain): occurrence and risk assessment." Journal of Environmental Monitoring 13, 2042-2049.
  6. A. Pal, K.Y.-H. Gin, A.Y.-C. Lin, M.Reinhard (2010), "Impacts of emerging organic contaminants on freshwater resources: review of recent occurrences, sources, fate and effects", Sci. Total Environ 408, 6062-6069
  7. European Medical Agency - National registers of authorised medicines
  8. pCure Product Definition
  9. pCure Standard Dissolving Test

SOURCES

  1. Drugbank, The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug data with comprehensive drug target information.
  2. PubChem, PubChem is the world's largest collection of freely accessible chemical information. Search chemicals by name, molecular formula, structure, and other identifiers
  3. ECHA, The European Chemicals Agency (ECHA) is the driving force among regulatory authorities in implementing the EU's groundbreaking chemicals legislation for the benefit of human health and the environment as well as for innovation and competitiveness.
  4. EMA, The mission of the European Medicines Agency (EMA) is to foster scientific excellence in the evaluation and supervision of medicines, for the benefit of public and animal health in the European Union (EU).
  5. EU watch-list, Commission Implementing Decision (EU) 2018/840 of 5 June 2018 establishing a watch list of substances for Union-wide monitoring in the field of water policy pursuant to Directive 2008/105/EC of the European Parliament.
  6. Umweltbundesamt, Since its founding in 1974, the German Environment Agency (Umweltbundesamt – UBA) has been Germany’s main environmental protection agency.
  7. Naturvårdsverket, A public agency in Sweden that is responsible for environmental issues. The Agency carries out assignments on behalf of the Swedish Government relating to the environment in Sweden, the EU and internationally
  8. Läkemedelsverket, The Swedish Medical Products Agency (MPA) is the Swedish national authority responsible for regulation and surveillance of the development, manufacturing and marketing of drugs and other medicinal products.
  9. FASS, The Swedish environmental classification of pharmaceuticals at www.fass.se has now been running since October 2005. Since then a large amount of environmental information of pharmaceuticals has been published.
  10. Janusinfo, Janusinfo is providing drug information to support healthcare professionals in their everyday work. The website is the electronic means of communication of the Drug Therapeutic Committee and the Health and Medical Care Administration of the Stockholm County Council, Sweden.