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Antidepressive Agents, Second-Generation

Antidepressive Agents, Second-Generation, Serotonin Uptake Inhibitors, Serotonin Agents


Adofen, Afeksin, Andepin, Bioxetin, Dagrilan, Deprex, Deprexetin, Exostrept, Felicium , Flonital, Floxet, Fluctine , Fluoxetine 1A Pharma , Fluoxetine 2care4, Fluoxetine AB, Fluoxetine AL, Fluoxetine AbZ, Fluoxetine Accord, Fluoxetine Actavis, Fluoxetine Almus, Fluoxetine Alter, Fluoxetine Amdipharm, Fluoxetine Apotex, Fluoxetine Arcana, Fluoxetine Aristo, Fluoxetine Arrow, Fluoxetine Aurobindo, Fluoxetine Aurovitas, Fluoxetine Azevedos, Fluoxetine BModesto, Fluoxetine Basi, Fluoxetine Benel, Fluoxetine Beta, Fluoxetine Biogaran, Fluoxetine Biomo, Fluoxetine Bluepharma, Fluoxetine CF, Fluoxetine Ciclum, Fluoxetine Cinfa, Fluoxetine Cristers, Fluoxetine Davur, Fluoxetine Dermogen, Fluoxetine Doc Generici, Fluoxetine Dura, Fluoxetine EGIS, Fluoxetine Ebb, Fluoxetine EuroGenerics, Fluoxetine Farmoz, Fluoxetine Fidia, Fluoxetine G.L., Fluoxetine GP, Fluoxetine Genericon, Fluoxetine Generics, Fluoxetine Generis, Fluoxetine Generis Phar, Fluoxetine Germed, Fluoxetine Hexal, Fluoxetine Jaba, Fluoxetine Kern Pharma, Fluoxetine Labesfal, Fluoxetine Lannacher, Fluoxetine Mabo, Fluoxetine Mylan, Fluoxetine Neuraxpharm, Fluoxetine Nodepe, Fluoxetine Normon, Fluoxetine Orifarm, Fluoxetine Orion, Fluoxetine Pharmakern, Fluoxetine Pharmex, Fluoxetine Polpharma, Fluoxetine Qualigen, Fluoxetine Ranbaxy, Fluoxetine Ratiopharm, Fluoxetine STADA, Fluoxetine Salipax, Fluoxetine Sandoz, Fluoxetine Tarbis, Fluoxetine Teva, Fluoxetine ToLife, Fluoxetine Tuneluz, Fluoxetine Uniche, Fluoxetine Vir, Fluoxetine Vitabalans, Fluoxetine Vitama, Fluoxetine Williams & Halls, Fluoxetine Wynn, Fluoxetine Zentiva, Fluoxetine Zydus, Fluoxetine-CT, Fluoxetine-RPh, Fluoxgamma, Fluoxone, Fluoxone Divule , Fluoxtab, Flustad, Fluval, Flux, Flux Hexal, Fluxemed, Fluxet, Fluxil, FluxoMed , Fluzac, Fluzak, Fodiss, Fokeston, Fontex, Gerozac, Ladose, Magrilan, Meropan, Mutan, Oxexin, Plazeron, Portal , Positivum, Prozac, Prozamel, Prozit, Psipax, Reconcile, Reneuron, Sartuzin, Selectus, Seromex, Seronil, Sofelin, Stephadilat, Stressless, Zinovat


fluoxetine, fluoxetine hydrochloride

Fluoxetine hydrochloride is the first agent of the class of antidepressants known as selective serotonin-reuptake inhibitors (SSRIs). Fluoxetine is a racemic mixture of the R- and S- enantiomers and are of equivalent pharmacologic activity. Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Fluoxetine may be used to treat major depressive disorder (MDD), moderate to severe bulimia nervosa, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), panic disorder with or without agoraphobia, and in combination with olanzapine for treatment-resistant or bipolar I depression. Fluoxetine is the most anorexic and stimulating SSRI.

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  4. EMA, The mission of the European Medicines Agency (EMA) is to foster scientific excellence in the evaluation and supervision of medicines, for the benefit of public and animal health in the European Union (EU).
  5. EU watch-list, Commission Implementing Decision (EU) 2018/840 of 5 June 2018 establishing a watch list of substances for Union-wide monitoring in the field of water policy pursuant to Directive 2008/105/EC of the European Parliament.
  6. Umweltbundesamt, Since its founding in 1974, the German Environment Agency (Umweltbundesamt – UBA) has been Germany’s main environmental protection agency.
  7. Naturvårdsverket, A public agency in Sweden that is responsible for environmental issues. The Agency carries out assignments on behalf of the Swedish Government relating to the environment in Sweden, the EU and internationally
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