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Miconazole

Antifungal Agents
CATEGORIES

Antifungal Agents, 14-alpha Demethylase Inhibitors


ALIASES

Cortimyk, Daktacort®, Daktar, Daktarin, Daktar®, Loramyc, Mikonazol CCS, Miconazex, Miconazole, Monistat, Monistat-Derm, Oravig, Rash Relief Antifungal, Zeasorb-AF, Zimycan


SUBSTANCES

miconazole, miconazole nitrate


ENVIRONMENTAL CONCERN: MODERATE
An imidazole antifungal agent that is used topically and by intravenous infusion. [PubChem]

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MODERATE
The T-value in the score for hazard refers to acute/chronic toxicity. Underlying data for P, B and T comes from Fass, see below.

Fass environmental information for Daktacort (hydrocortisone, miconazole) for miconazole (downloaded 2018-06-27)


Hazard
Persistence: "Miconazole nitrate is potentially persistent."

Bioaccumulation: BCF = 1 949.

Chronic toxicity: There is NOEC for 3 trophic levels, lowest NOEC for green algae (Selenastrum capricornutum) NOECr 72 h = 10 microg/L.

Risk
PEC/PNEC is based on sales data in Sweden in year 2015. PEC/PNEC = 0.3455 which gives the risk low.

REFERENCES

  1. Fass.se för vårdpersonal