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Asmanex® Twisthaler®, Demoson, Elocom, Elocon®, Elosalic®, Mometason ABECE, Mometason Apofri, Mometason Glenmark, Mometason Orion, Mometasone Actavis, Mometasone Teva, Mommox, Nasomet, Nasonex, Nasonex®, Orimox, Ovixan


mometasone, mometasone furoate, mometasone furoate monohydrate

Mometasone is a medium-potency synthetic corticosteroid with antiinflammatory, antipruritic, and vasoconstrictive properties. Studies in asthmatic patients have demonstrated that mometasone provides a favorable ratio of topical to systemic activity due to its primary local effect along with the extensive hepatic metabolism and the lack of active metabolites. Though effective for the treatment of asthma, glucocorticoids do not affect asthma symptoms immediately. Maximum improvement in symptoms following inhaled administration of mometasone furoate may not be achieved for 1 to 2 weeks or longer after starting treatment. he antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

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The T-value in the score for hazard refers to acute/chronic toxicity. Underlying data for P, B, T and risk comes from Fass.se.

Below is Hazard and Risk from Fass environmental information for Asmanex Twisthaler (mometasone) (downloaded 2018-07-04)

Persistence: "DT50 (total system) = 81 to 105 days (OECD 308)." Mometasone is slowly degraded in the environment.

Bioaccumulation: Log Kow: pH 5 = 4.66, pH 7 = 4.68, pH 9 = 4.81. "BCFwhole body, total residues = 104.9 to 107.1. Since BCF < 500, mometasone furoate has low potential for bioaccumulation."

Chronic toxicity: There is NOEC for 3 trophic levels, lowest fish (Pimephales promelas) (OECD 210) NOEC 32d (total length and dry weight) = 0.14 microg/L.

PEC/PNEC is based on sales data in Sweden in year 2015. PEC/PNEC = 0.42 which gives the risk low.


  1. Fass.se för vårdpersonal