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Mycophenolic acid

Immunosuppressive Agents
CATEGORIES

Immunosuppressive Agents


ALIASES

CellCept®, Myclausen, Mycophenolate mofetil Accord, Mycophenolate mofetil Arrow, Mycophenolate mofetil Cross Pharma, Mycophenolate mofetil Sandoz, Myfenax, Myfortic, Myfortic®, Mykofenolatmofetil 2care4, Mykofenolatmofetil Accord, Mykofenolatmofetil Actavis, Mykofenolatmofetil Orifarm, Mykofenolatmofetil Stada


SUBSTANCES

mycophenolic acid


ENVIRONMENTAL CONCERN: MODERATE
Mycophenolate mofetil is the 2-morpholinoethyl ester of mycophenolic acid (MPA), an immunosuppressive agent, inosine monophosphate dehydrogenase (IMPDH) inhibitor.

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MODERATE
The T-value in the score for hazard refers to acute/chronic toxicity. Underlying data for P, B, T and risk comes from Fass.se.

Below is Hazard and Risk from Fass environmental information for Myfortic (mycophenolic acid) (downloaded 2018-07-02)


Hazard
Persistence: "2.0–5.0 % degradation in 28 days, not readily biodegradable (OECD301)."

Bioaccumulation: Log P: 1.6

Acute toxicity: There are data for 3 trophic levels, lowest for algae (Selenastrum capricornutum) 68 microg/L.

Risk
PEC/PNEC is based on sales data in Sweden in year 2015. PEC/PNEC = 5.21 which gives the risk moderate.

REFERENCES

  1. Fass.se för vårdpersonal