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Paclitaxel

Antineoplastic Agents, Phytogenic
CATEGORIES

Antineoplastic Agents, Phytogenic, Tubulin Modulators


ALIASES

Abraxane, Paclical, Pacligen, Paclitaxel, Paclitaxel Accord, Paclitaxel Actavis, Paclitaxel Ebewe, Paclitaxel Fresenius Kabi, Paclitaxel Pfizer, Paclitaxel Teva, Paclitaxel ratiopharm, Pacovary, Paxene, Taxol


SUBSTANCES

paclitaxel


ENVIRONMENTAL CONCERN: MODERATE
Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a US National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it taxol. Later it was discovered that endophytic fungi in the bark synthesize paclitaxel. When it was developed commercially by Bristol-Myers Squibb (BMS), the generic name was changed to paclitaxel and the BMS compound is sold under the trademark Taxol. In this formulation, paclitaxel is dissolved in Kolliphor EL and ethanol, as a delivery agent. A newer formulation, in which paclitaxel is bound to albumin, is sold under the trademark Abraxane. [Wikipedia]

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MODERATE
Detailed information about this substance is missing and will added when a credible source of information has been identified.