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Roxithromycin

Macrolides
CATEGORIES

Macrolides


ALIASES

Ai Luo Xin, Allolide, Ammirox, Anti-Bio, Ao Ge Shen, Aparox, Arbid, Aroxe, Asmetic, Assoral, Aswad, Azuril, BD-Rox, Bazuctril, Bei Ke, Bei Sha, Bi Ai Di, Biaxsig, Bicofen, Biostatik, Claramid, Coroxin, Delitroxin, Delos, Dorolid, Elrox, Erybros, Eslid, Guamil, Heng Te, Hycin, I-Throcin, Infectoroxit, Inrox, Ixor, Klomicina, Ladlid, Lang Su, Le Er Tai, Le Xi Qing, Li Fu, Lizhuxing, Ludin, Luo Jun Qing, Luo Shi Li, Luo Si Mei, Luprex, Macrol, Macrolid, Marulide, Neo-Suxigal, Nirox, Odirox, Overal, Pedilid, Pedrox, Pinsheng, Plethirox, Poliroxin, Pu Hong, Pymeroxitil, Qi Wei, Ramivan, Redotrin, Remora, Ren Su, Renicin, Ridinfect, Ritosin, Rocin, Rokithrid, Roksimin, Rolexit, Rolicyn, Romac, Romicin, Romycin, Romyk, Ropit, Rossitrol, Rothricin, Rotram, Rovenal, Roxamed, Roxar, Roxcin, Roxemicin, Roxeptin, Roxetomin, Roxi, Roxi-Fatol, Roxi-Puren, Roxi-Q, Roxi-saar, Roxibest, Roxibeta, Roxibron, Roxicin, Roxicur, Roxicure, Roxid, Roxide, Roxidura, Roxigamma, Roxigrün, Roxihexal, Roxikid, Roxil, Roxilan, Roximac, Roximain, Roximax, Roximed, Roximerck, Roximic, Roximin, Roximisan, Roximol, Roximstad, Roximycin, Roxinga, Roxinox, Roxiratio, Roxirocin, Roxisara, Roxistad, Roxitas, Roxitazon, Roxithrin, Roxithro, Roxithromycin, Roxithrostad, Roxitil, Roxitin, Roxitis, Roxitop, Roxitran, Roxitrom, Roxitromycine, Roxitron, Roxivar, Roxivinol, Roxivista, Roxl-150, Roxo, Roxomycin, Roxy, Roxy-150, Rulid, Rulide, Rulide D, Surlid, Surlid®, Tirabicin, Xthrocin


SUBSTANCES

roxithromycin


ENVIRONMENTAL CONCERN: HIGH
Roxithromycin is a semi-synthetic macrolide antibiotic. It is very similar in composition, chemical structure and mechanism of action to erythromycin, azithromycin, or clarithromycin. Roxithromycin prevents bacteria from growing, by interfering with their protein synthesis. Roxithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides. Roxithromycin has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila. It can treat respiratory tract, urinary and soft tissue infections. It is not available in the United States, but is available in Australia.

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IN SCOPE
HIGH

REFERENCES

  1. Goodpoint. Prioritering av läkemedel med miljörisk inom SLL. Stockholm: Goodpoint; 2016. Rapport LS 2016–0634.
  2. IVL Swedish Environmental Research Institute Ltd. Fick J, Lindberg RH, Kaj L, Brorström-Lundén E. Results from the Swedish National Screening Programme 2010. Subreport 3. Pharmaceuticals.
  3. IVL Swedish Environmental Research Institute Ltd Fick J, Lindberg RH, Fång J, Magnér J, Kaj L, Brorström-Lundén E. Screening 2014. Analysis of pharmaceuticals and hormones in samples from WWTPs and receiving waters. Rapport C 135.
  4. Yang LH, Ying GG, Su HC, Stauber JL, Adams MS, Binet MT. Growth-inhibiting effects of 12 antibacterial agents and their mixtures on the freshwater microalga Pseudokirchneriella subcapitata. Environ Toxicol Chem. 2008;27:1201-8.
  5. Bengtsson-Palme J, Larsson DG. Concentrations of antibiotics predicted to select for resistant bacteria: Proposed limits for environmental regulation. Environ Int. 2016;86:140-9.
  6. Gullberg E, Cao S, Berg OG, Ilbäck C, Sandegren L, Hughes D et al. Selection of resistant bacteria at very low antibiotic concentrations. PLoS Pathog. 2011;7:e1002158.
  7. Stockholms läns landsting. Förteckning över miljöbelastande läkemedel med åtgärdsförslag framtagen inom ramen för SLL:s miljöprogram 2017–2021.
  8. Fass.se för vårdpersonal
  9. Socialstyrelsen. Statistikdatabas för läkemedel.
  10. Stockholms läns landsting. Janusinfo: Läkemedelsuppföljning

SOURCES

  1. Drugbank, The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug data with comprehensive drug target information.
  2. PubChem, PubChem is the world's largest collection of freely accessible chemical information. Search chemicals by name, molecular formula, structure, and other identifiers
  3. ECHA, The European Chemicals Agency (ECHA) is the driving force among regulatory authorities in implementing the EU's groundbreaking chemicals legislation for the benefit of human health and the environment as well as for innovation and competitiveness.
  4. EMA, The mission of the European Medicines Agency (EMA) is to foster scientific excellence in the evaluation and supervision of medicines, for the benefit of public and animal health in the European Union (EU).
  5. EU watch-list, Commission Implementing Decision (EU) 2018/840 of 5 June 2018 establishing a watch list of substances for Union-wide monitoring in the field of water policy pursuant to Directive 2008/105/EC of the European Parliament.
  6. Umweltbundesamt, Since its founding in 1974, the German Environment Agency (Umweltbundesamt – UBA) has been Germany’s main environmental protection agency.
  7. Naturvårdsverket, A public agency in Sweden that is responsible for environmental issues. The Agency carries out assignments on behalf of the Swedish Government relating to the environment in Sweden, the EU and internationally
  8. Läkemedelsverket, The Swedish Medical Products Agency (MPA) is the Swedish national authority responsible for regulation and surveillance of the development, manufacturing and marketing of drugs and other medicinal products.
  9. FASS, The Swedish environmental classification of pharmaceuticals at www.fass.se has now been running since October 2005. Since then a large amount of environmental information of pharmaceuticals has been published.
  10. Janusinfo, Janusinfo is providing drug information to support healthcare professionals in their everyday work. The website is the electronic means of communication of the Drug Therapeutic Committee and the Health and Medical Care Administration of the Stockholm County Council, Sweden.