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Antidepressive Agents

Antidepressive Agents, Serotonin Uptake Inhibitors


Ainim, Altisben, ApoSerta, Aremis, Asentra, Aserin, Asertin, Besitran, Certorun, Covibra, Depreger, Diticone, Enidap, Enore, Epilyd, Gladem, Halea, Lustral, Luxeta, Mapron, Miravil, Neurosedine, Oralin, Sastium, Serimel, Serlain, Serlan, Serlin, Serlinan, Serolux, Seromeg, Serotyp, Sertivan, Sertral, Sertralet, Sertraline 123ratio, Sertraline 1A Pharma, Sertraline AAA-Pharma, Sertraline AL, Sertraline AbZ, Sertraline Accord, Sertraline Actavis, Sertraline Almus, Sertraline Alter, Sertraline Anova, Sertraline Apotex, Sertraline Aristo, Sertraline Arrow, Sertraline Aserta, Sertraline Atral, Sertraline Auro, Sertraline Aurobindo, Sertraline Aurovitas, Sertraline Azevedos, Sertraline BModesto, Sertraline Basi, Sertraline Basics, Sertraline Beta, Sertraline Bexal, Sertraline Biogaran, Sertraline Biomo, Sertraline Bluefish, Sertraline Bluepharma, Sertraline Ciclum, Sertraline Cinfa, Sertraline Cristers, Sertraline Davur, Sertraline Doc Generici, Sertraline Dura, Sertraline ERC, Sertraline Easypharm, Sertraline Eurogeneric, Sertraline Evolugen, Sertraline Farmax, Sertraline Farmoz, Sertraline G.L., Sertraline GP, Sertraline Genedec, Sertraline Genericon, Sertraline Generis, Sertraline Generis Phar, Sertraline Germed, Sertraline Gluvat, Sertraline Heumann, Sertraline Hexal , Sertraline Hormosan, Sertraline J. Neves, Sertraline JS Partner, Sertraline Jaba, Sertraline Kern Pharma, Sertraline Krka, Sertraline Lannacher, Sertraline Mabo, Sertraline Mylan, Sertraline Neuraxpharm, Sertraline Normon, Sertraline Orion, Sertraline Pensa, Sertraline Pfizer, Sertraline Pharma Combix, Sertraline Pharmakern, Sertraline Puren, Sertraline Qualigen, Sertraline Quimedical, Sertraline RIA, Sertraline Ranbaxy, Sertraline Ratiopharm, Sertraline STADA, Sertraline SUN, Sertraline SVUS, Sertraline Sandoz , Sertraline Sertabal, Sertraline Somidal, Sertraline Tecnigen, Sertraline Tetrafarma, Sertraline Teva, Sertraline ToLife, Sertraline Vale, Sertraline Vipharm, Sertraline Vir, Sertraline Vitama, Sertraline Winthrop, Sertraline Wynn, Sertraline Zentiva, Sertraline Zydus France, Sertraline-CT, Sertralon, Sertramyl, Sertranat, Sertrone, Serunato, Setaloft, Setragen, Setranorm, Setrrix, Setrrone, Sonalia, Stimuloton, Tatig, Tralin, Tralinan, Tralisen, Tralix, Tresleen, Zeelinax, Zoloft, Zolotrin, Zortal


sertraline, sertraline hydrochloride

Sertraline hydrochloride belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache (see Toxicity section below for a more detailed listing of side effects). Compared to other agents in this class, sertraline may cause greater diarrheal and male sexual dysfunction effects. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Sertraline may be used to treat major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD) and social anxiety disorder (social phobia).

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  4. EMA, The mission of the European Medicines Agency (EMA) is to foster scientific excellence in the evaluation and supervision of medicines, for the benefit of public and animal health in the European Union (EU).
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