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Sertraline

Antidepressive Agents
CATEGORIES

Antidepressive Agents, Serotonin Uptake Inhibitors


ALIASES

Ainim, Altisben, ApoSerta, Aremis, Asentra, Aserin, Asertin, Besitran, Certorun, Covibra, Depreger, Diticone, Enidap, Enore, Epilyd, Gladem, Halea, Lustral, Luxeta, Mapron, Miravil, Neurosedine, Oralin, Sastium, Serimel, Serlain, Serlan, Serlin, Serlinan, Serolux, Seromeg, Serotyp, Sertivan, Sertral, Sertralet, Sertraline 123ratio, Sertraline 1A Pharma, Sertraline AAA-Pharma, Sertraline AL, Sertraline AbZ, Sertraline Accord, Sertraline Actavis, Sertraline Almus, Sertraline Alter, Sertraline Anova, Sertraline Apotex, Sertraline Aristo, Sertraline Arrow, Sertraline Aserta, Sertraline Atral, Sertraline Auro, Sertraline Aurobindo, Sertraline Aurovitas, Sertraline Azevedos, Sertraline BModesto, Sertraline Basi, Sertraline Basics, Sertraline Beta, Sertraline Bexal, Sertraline Biogaran, Sertraline Biomo, Sertraline Bluefish, Sertraline Bluepharma, Sertraline Ciclum, Sertraline Cinfa, Sertraline Cristers, Sertraline Davur, Sertraline Doc Generici, Sertraline Dura, Sertraline ERC, Sertraline Easypharm, Sertraline Eurogeneric, Sertraline Evolugen, Sertraline Farmax, Sertraline Farmoz, Sertraline G.L., Sertraline GP, Sertraline Genedec, Sertraline Genericon, Sertraline Generis, Sertraline Generis Phar, Sertraline Germed, Sertraline Gluvat, Sertraline Heumann, Sertraline Hexal , Sertraline Hormosan, Sertraline J. Neves, Sertraline JS Partner, Sertraline Jaba, Sertraline Kern Pharma, Sertraline Krka, Sertraline Lannacher, Sertraline Mabo, Sertraline Mylan, Sertraline Neuraxpharm, Sertraline Normon, Sertraline Orion, Sertraline Pensa, Sertraline Pfizer, Sertraline Pharma Combix, Sertraline Pharmakern, Sertraline Puren, Sertraline Qualigen, Sertraline Quimedical, Sertraline RIA, Sertraline Ranbaxy, Sertraline Ratiopharm, Sertraline STADA, Sertraline SUN, Sertraline SVUS, Sertraline Sandoz , Sertraline Sertabal, Sertraline Somidal, Sertraline Tecnigen, Sertraline Tetrafarma, Sertraline Teva, Sertraline ToLife, Sertraline Vale, Sertraline Vipharm, Sertraline Vir, Sertraline Vitama, Sertraline Winthrop, Sertraline Wynn, Sertraline Zentiva, Sertraline Zydus France, Sertraline-CT, Sertralon, Sertramyl, Sertranat, Sertrone, Serunato, Setaloft, Setragen, Setranorm, Setrrix, Setrrone, Sonalia, Stimuloton, Tatig, Tralin, Tralinan, Tralisen, Tralix, Tresleen, Zeelinax, Zoloft, Zolotrin, Zortal


SUBSTANCES

sertraline, sertraline hydrochloride


ENVIRONMENTAL CONCERN: HIGH
Sertraline hydrochloride belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache (see Toxicity section below for a more detailed listing of side effects). Compared to other agents in this class, sertraline may cause greater diarrheal and male sexual dysfunction effects. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Sertraline may be used to treat major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD) and social anxiety disorder (social phobia).

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VERIFIED EFFECT
HIGH

REFERENCES

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  2. Metcalfe, C. D., S. Chu, C. Judt, H. Li, K. D. Oakes, Servos, M. R., Andrews, D. M (2010). "Antidepressants and their metabolites in municipal wastewater, and downstream exposure in an urban watershed." Environ Toxicol Chem 29: 79-89.
  3. Vasskog, T., T. Anderssen, S. Pedersen-Bjergaard, R. Kallenborn and E. Jensen (2008). "Occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at Spitsbergen and in Norway." J. Chromatogr. A 1185: 194-205.
  4. Valenti, T. W., Perez‐Hurtado, P. , Chambliss, C. K. and Brooks, B. W. (2009), Aquatic toxicity of sertraline to Pimephales promelas at environmentally relevant surface water pH. Environ Toxicol Chem, 28: 2685-2694. doi:10.1897/08-546.1
  5. Minagh, E,. Hernan, R., O’Rourke, K., Lyng, M. F., Davoren, M., (2009) “Aquatic ecotoxicity of the selective serotonin reuptake inhibitor sertraline hydrochloride in a battery of freshwater test species, Ecotoxicol Environ Saf, V.72, 434-440,
  6. Ribeiro, S., Torres, T., Martins, R., Santos, M. M., (2015) “Toxicity screening of Diclofenac, Propranolol, Sertraline and Simvastatin using Danio rerio and Paracentrotus lividus embryo bioassays, Ecotoxicol Environ Saf, V.114, 67-74,
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  8. Johnson DJ, Sanderson H, Brain RA, Wilson CJ, Solomon KR. Toxicity and hazard of selective serotonin reuptake inhibitor antidepressants fluoxetine, fluvoxamine, and sertraline to algae. Ecotoxicology and Environmental Safety. 2007;67:128–139.
  9. IVL Swedish Environmental Research Institute Ltd. Fick J, Lindberg RH, Kaj L, Brorström-Lundén E. Results from the Swedish National Screening Programme 2010. Subreport 3. Pharmaceuticals.
  10. IVL Swedish Environmental Research Institute Ltd Fick J, Lindberg RH, Fång J, Magnér J, Kaj L, Brorström-Lundén E. Screening 2014. Analysis of pharmaceuticals and hormones in samples from WWTPs and receiving waters. Rapport C 135.
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  12. Goodpoint. Prioritering av läkemedel med miljörisk inom SLL. Stockholm: Goodpoint; 2016. Rapport LS 2016–0634.
  13. SLL. Sammanställning av läkemedelsprovtagningar - Bearbetning av regional försäljningsstatistik av läkemedel samt datamaterial från Stockholms läns landstings mätprogram för läkemedelssubstanser i vattenmiljö, 2012–2016.
  14. Stockholms läns landsting. Förteckning över miljöbelastande läkemedel med åtgärdsförslag framtagen inom ramen för SLL:s miljöprogram 2017–2021.
  15. Goodpoint. Jämförande bedömning av miljörisk vid användning av citalopram, escitalopram, sertralin, fluoxetin, venlafaxin, paroxetin och klomipramin. Stockholm: Goodpoint; 2018.
  16. European Medical Agency - National registers of authorised medicines
  17. pCure Product Definition
  18. pCure Standard Dissolving Test

SOURCES

  1. Drugbank, The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug data with comprehensive drug target information.
  2. PubChem, PubChem is the world's largest collection of freely accessible chemical information. Search chemicals by name, molecular formula, structure, and other identifiers
  3. ECHA, The European Chemicals Agency (ECHA) is the driving force among regulatory authorities in implementing the EU's groundbreaking chemicals legislation for the benefit of human health and the environment as well as for innovation and competitiveness.
  4. EMA, The mission of the European Medicines Agency (EMA) is to foster scientific excellence in the evaluation and supervision of medicines, for the benefit of public and animal health in the European Union (EU).
  5. EU watch-list, Commission Implementing Decision (EU) 2018/840 of 5 June 2018 establishing a watch list of substances for Union-wide monitoring in the field of water policy pursuant to Directive 2008/105/EC of the European Parliament.
  6. Umweltbundesamt, Since its founding in 1974, the German Environment Agency (Umweltbundesamt – UBA) has been Germany’s main environmental protection agency.
  7. Naturvårdsverket, A public agency in Sweden that is responsible for environmental issues. The Agency carries out assignments on behalf of the Swedish Government relating to the environment in Sweden, the EU and internationally
  8. Läkemedelsverket, The Swedish Medical Products Agency (MPA) is the Swedish national authority responsible for regulation and surveillance of the development, manufacturing and marketing of drugs and other medicinal products.
  9. FASS, The Swedish environmental classification of pharmaceuticals at www.fass.se has now been running since October 2005. Since then a large amount of environmental information of pharmaceuticals has been published.
  10. Janusinfo, Janusinfo is providing drug information to support healthcare professionals in their everyday work. The website is the electronic means of communication of the Drug Therapeutic Committee and the Health and Medical Care Administration of the Stockholm County Council, Sweden.
DOWNLOADS
Verification statement: pCure effect towards Sertraline
Verification report: Verified effect of pCure towards Sertraline in Sewage Water