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Terbinafine

Antifungal Agents
CATEGORIES

Antifungal Agents


ALIASES

Funginix®, Lamisil®, Lamisil® Dermgel, Lamisil® Singeldos, Terbinafin ABECE, Terbinafin Actavis, Terbinafin Apofri, Terbinafin Arrow, Terbinafin Bluefish, Terbinafin Galderma, Terbinafin Hexal, Terbinafin IVAX, Terbinafin Medical Valley, Terbinafin Mylan, Terbinafin Nordic Drugs, Terbinafin Orifarm, Terbinafin Rivopharm, Terbinafin STADA, Terbinafin Teva, Terbinafin ratiopharm, Terbisil


SUBSTANCES

terbinafine, terbinafine hydrochloride


ENVIRONMENTAL CONCERN: MODERATE
Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (squalene 2,3-epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway.

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MODERATE
The T-value in the score for hazard refers to chronic toxicity. Underlying data for P, B and T comes from Fass.se.

Below is Hazard and Risk from Fass environmental information for Lamisil Dermgel (terbinafine) (downloaded 2018-07-02)


Hazard
Persistence: "Degradation - DT50 (freshwater phase) = 3-8 days DT50 (total system) = 16-31 days. The DT50 32 days therefore the phrase ‘The substance is degraded in the environment’ is chosen."

Bioaccumulation: "Partition Coefficient: log Kow 5.2 (22.0 °C, OECD107). BCF calculated: 5248"

Chronic toxicity: There is NOEC for 3 trophic levels, lowest NOEC for green algae (Pseudokirchneriella subspicata) 0.53 microg/L.

Risk
PEC/PNEC is based on sales data in Sweden in year 2016. PEC/PNEC = 1.62 which gives the risk moderate.

REFERENCES

  1. Fass.se för vårdpersonal