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Timolol

Antihypertensive Agents
CATEGORIES

Antihypertensive Agents, Anti-Arrhythmia Agents, Adrenergic beta-Antagonists


ALIASES

AZARGA, Aquanil®, Blocadren Depot, Blocadren®, Blocadren® Depot, Combigan, Combigan®, Cosopt, Cosopt sine, Cosopt®, Costad, Dorzolamid/Timolol Actavis, Dorzolamid/Timolol Sandoz, Dorzolamide/Timolol Teva, DuoTrav, Duokopt, Fotil, Fotil forte, Ganfort, Latacomp, Latanoprost/Timolol 2care4, Latanoprost/Timolol Pfizer, Latiotim, Optimol, Taptiqom, Timolol Alcon, Timolol CCS, Timoptol LA, Timosan, Timpilo®, Timpilo® forte, Travoprost/Timolol STADA, Xalcom, Xalcom®, Xatabloc


SUBSTANCES

timolol, timolol maleate, timolol maleate, r-enantiomer


ENVIRONMENTAL CONCERN: MODERATE
A beta-adrenergic antagonist similar in action to propranolol. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of migraine disorders and tremor. [PubChem]

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MODERATE
Underlying data for P, B, T and risk are from Fass.

Below is information about timolol from Scientific discussion for Ganfort (bimatoprost, timolol) EMA 2006
"The PECsurfacewater values from the Phase I exposure assessment of bimatoprost and timolol were calculated to 8.4 x 10-6 and 1.4 x 10-5 μg/L, which is significantly less than the action limit of 0.01 μg/L described in the draft guideline “Guideline on the Environmental Risk Assessment of Medicinal products for Human use”. Ganfort is unlikely to pose a risk to the environment."

Below is Hazard and Risk from Fass environmental information for timolol from Azarga (brinzolamide, timolol) (downloaded 2018-10-30)


Hazard
Persistence: No data.

Bioaccumulation: log Kow = 1.8 (method unknown).

Toxicity: No data.

Risk

"Calculation of a risk ratio is not possible, due to the lack of environmental toxicity data."

REFERENCES

  1. Fass.se för vårdpersonal
  2. European Medicines Agency. European public assessment reports (EPAR).