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Trandolapril

Angiotensin-Converting Enzyme Inhibitors
CATEGORIES

Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents


ALIASES

Gopten, Tarka, Tarka LP, Tarka®


SUBSTANCES

trandolapril


ENVIRONMENTAL CONCERN: MODERATE
Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Trandolapril may be used to treat mild to moderate hypertension, to improve survival following myocardial infarction in clinically stable patients with left ventricular dysfunction, as an adjunct treatment for congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.

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MODERATE
Detailed information about this substance is missing and will added when a credible source of information has been identified.