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Zopiclone

Hypnotics and Sedatives
CATEGORIES

Hypnotics and Sedatives


ALIASES

Imovane®, Zopiclon Copyfarm, Zopiclon Stada, Zopiclone Actavis, Zopiclone Jubilant, Zopiclone Orion, Zopiklon Mylan, Zopiklon Pilum, Zopiklon Scand Pharm


SUBSTANCES

zopiclone


ENVIRONMENTAL CONCERN: MODERATE
Zopiclone is a novel hypnotic agent used in the treatment of insomnia. Its mechanism of action is based on modulating benzodiazepine receptors. In addition to zopiclone's benzodiazepine pharmacological properties it also has some barbiturate like properties.

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MODERATE
Below is Hazard and Risk according to data from Fass environmental information for Imovane (zopiclone) (downloaded 2018-06-15)


Hazard
Persistence: No data.

Bioaccumulation: "log Kow of 1.54 (unknown method)."

Toxicity: No data.

Risk
Risk of environmental impact of zopiclone can not be excluded since ecotoxicological data are missing.

Reference Goodpoint. Prioritering av läkemedel med miljörisk inom SLL. Stockholm: Goodpoint; 2016. Rapport LS 2016–0634
Environmental data for zopiclone is lacking, but no existing data indicates a high risk of environmental impact in Swedish water systems. The substance has low potential for bioaccumulation.

REFERENCES

  1. Fass.se för vårdpersonal
  2. Goodpoint. Prioritering av läkemedel med miljörisk inom SLL. Stockholm: Goodpoint; 2016. Rapport LS 2016–0634.
  3. IVL Swedish Environmental Research Institute Ltd Fick J, Lindberg RH, Fång J, Magnér J, Kaj L, Brorström-Lundén E. Screening 2014. Analysis of pharmaceuticals and hormones in samples from WWTPs and receiving waters. Rapport C 135.
  4. IVL Swedish Environmental Research Institute Ltd. Fick J, Lindberg RH, Kaj L, Brorström-Lundén E. Results from the Swedish National Screening Programme 2010. Subreport 3, B 2014 Pharmaceuticals.
  5. Fick J, Lindberg RH, Tysklind M, Larsson DG. Predicted critical environmental concentrations for 500 pharmaceuticals. Regul Toxicol Pharmacol. 2010;58:516-23.